Endometrial Receptivity Array Testing
What is Endometrial Receptivity Array Testing (ERA)?
Endometrial receptivity is an important part of IVF success. Today, IVF laboratories are capable of supporting excellent embryonic development under in-vitro conditions. However, in order for a successful pregnancy to be achieved, the embryo must implant, and establish a connection to the maternal circulation. This process requires that the endometrium must be receptive. The so-called “window of receptivity” of the endometrium and the interaction between the embryo and the uterine lining is only beginning to be understood.
For the majority of women the best day for a given aged embryo to implant agrees with the corresponding day of a woman’s menstrual cycle. It is becoming increasingly apparent, however, that for some women, their “window of receptivity” is a different to that suggested by their menstrual timing alone.
A pipette biopsy of the endometrium in a "mock" embryo replacement cycle can determine whether the endometrium is receptive at that time or whether embryos would be better replaced a day earlier or later to assist with implantation. This new era of patient management is termed “personalised IVF.” There is obviously a time factor and cost to performing these tests, but for some patients, the resulting change in embryo transfer timing gives them the baby they have strived for.